Astrophysical neutrinos flavored with Beyond the Standard Model physics

We systematically study the allowed parameter space for the flavor composition of astrophysical neutrinos measured at Earth, including beyond the Standard Model theories at production, during propagation, and at detection. One motivation is to illustrate the discrimination power of the next-generation neutrino telescopes such as IceCube-Gen2. We identify several examples that lead to potential deviations from the standard neutrino mixing expectation such as significant sterile neutrino production at the source, effective operators modifying the neutrino propagation at high energies, dark matter interactions in neutrino propagation, or non-standard interactions in Earth matter. IceCube-Gen2 can exclude about 90% of the allowed parameter space in these cases, and hence will allow to efficiently test and discriminate models. More detailed information can be obtained from additional observables such as the energy-dependence of the effect, fraction of electron antineutrinos at the Glashow resonance, or number of tau neutrino events.Comment: 21 pages, 9 figures, 3 tables, v2: references added, typos corrected, conclusion unchanged, matches final version in PR

Machine learning applications for the study of AGN physical properties using photometric observations

We investigate the physical nature of Active Galactic Nuclei using machine learning tools. We show that the redshift $z$, the bolometric luminosity $L_{\rm Bol}$, the central mass of the supermassive black hole $M_{\rm BH}$, the Eddington ratio $\lambda_{\rm Edd}$ as well as the AGN class (obscured or unobscured) can be reconstructed through multi-wavelength photometric observations only. A Support Vector Regression (SVR) ML-model is trained on 7616 of spectroscopically observed AGN from the SPIDERS-AGN survey, previously cross-matched with soft X-ray observations (from ROSAT or XMM), WISE mid-infrared photometry, and optical photometry from SDSS $ugriz$ filters. We build a catalogue of 21364 AGN to be reconstructed with the trained SVR: for 9944 sources, we found archival redshift measurements. All AGN are classified as either Type 1/2 using a Random Forest (RF) algorithm on a subset of known sources. All known photometric measurement uncertainties are incorporated using a simulation-based approach. We present the reconstructed catalogue of 21364 AGN with redshifts ranging from $0 < z < 2.5$. $z$ estimations are made for 11420 new sources, with an outlier rate within 10%. Type 1/2 AGN can be identified with respective efficiencies of 88% and 93%: the estimated classification of all sources is given in the dataset. $L_{\rm Bol}$, $M_{\rm BH}$, and $\lambda_{\rm Edd}$ values are given for 16907 new sources with their estimated error. These results have been made publicly available. The release of this catalogue will advance AGN studies by presenting key parameters of the accretion history of 6 dex in luminosity over a wide range of $z$. Similar applications of ML techniques using photometric data only will be essential in the future, with large datasets from eROSITA, JSWT and the VRO poised to be released in the next decade.Comment: 20 pages, 24 figures, submitted to A&

Introducing the MeVCube concept: a CubeSat for MeV observations

Despite the impressive progress achieved both by X-ray and gamma-ray observatories in the last few decades, the energy range between ∼ 200 keV and ∼ 50 MeV remains poorly explored. COMPTEL, on-board the Compton Gamma-Ray Observatory (CGRO, 1991-2000), opened the MeV gamma-ray band as a new window to astronomy, performing the first all-sky survey in the energy range from 0.75 to 30 MeV. More than 20 years after the de-orbit of CGRO, no successor mission is yet operating. Over the past years many concepts have been proposed, for new observatories exploring different configurations and imaging techniques; a selection of the most recent ones includes AMEGO, ETCC, GECCO and COSI. We propose here a novel concept for a Compton telescope based on the CubeSat standard, named MeVCube, with the advantages of small cost and relatively short development time. The scientific payload is based on two layers of pixelated Cadmium-Zinc-Telluride (CdZnTe) detectors, coupled with low-power read-out electronics (ASIC, VATA450.3). The performance of the read-out electronics and CdZnTe custom designed detectors have been measured extensively at DESY [1]. The performance of the telescope is accessed through simulations: despite a small effective area limited to a few cm2, MeVCube can reach an angular resolution of 1.5° and a sensitivity comparable to the one achieved by the last generation of large-scale satellites like COMPTEL and INTEGRAL. Combined with a large field-of-view and a moderate cost, MeVCube can be a powerful instrument for transient observations and searches of electromagnetic counterparts of gravitational wave events.Peer Reviewe

Introducing the MeVCube concept: a CubeSat for MeV observations

Despite the impressive progress achieved both by X-ray and gamma-ray observatories in the last few decades, the energy range between $\sim200\;\mathrm{keV}$ and $\sim50\;\mathrm{MeV}$ remains poorly explored. COMPTEL, on-board the Compton Gamma-Ray Observatory (CGRO, $1991$-$2000$), opened the MeV gamma-ray band as a new window to astronomy, performing the first all-sky survey in the energy range from $0.75$ to $30\;\mathrm{MeV}$. More than $20$ years after the de-orbit of CGRO, no successor mission is yet operating. Over the past years many concepts have been proposed, for new observatories exploring different configurations and imaging techniques; a selection of the most recent ones includes AMEGO, ETCC, GECCO and COSI. We propose here a novel concept for a Compton telescope based on the CubeSat standard, named MeVCube, with the advantages of small cost and relatively short development time. The scientific payload is based on two layers of pixelated Cadmium-Zinc-Telluride (CdZnTe) detectors, coupled with low-power read-out electronics (ASIC, VATA450.3). The performance of the read-out electronics and CdZnTe custom designed detectors have been measured extensively at DESY. The performance of the telescope is accessed through simulations: despite a small effective area limited to a few $\mathrm{cm}^{2}$, MeVCube can reach an angular resolution of $1.5^{\circ}$ and a sensitivity comparable to the one achieved by the last generation of large-scale satellites like COMPTEL and INTEGRAL. Combined with a large field-of-view and a moderate cost, MeVCube can be a powerful instrument for transient observations and searches of electromagnetic counterparts of gravitational wave events

A preliminary phylogeny of Loasaceae subfam. Loasoideae (Angiospermae: Cornales) based on trnL(UAA) sequence data, with consequences for systematics and historical biogeography

AbstractThe phylogeny of Loasaceae subfam. Loasoideae is investigated with sequences of the chloroplast trnL(UAA) intron, all genera and infrageneric entities are included in the analysis. Loasaceae subfam. Loasoideae is monophyletic, and the two most speciose, and monophyletic, clades (which account for approximately 90% of the species total) are Nasa and the so-called Southern Andean Loasas (Blumenbachia, Caiophora, Loasa s.str., Scyphanthus), but the phylogeny of the remainder is not completely resolved. The data underscore a basal position for Chichicaste, Huidobria, Kissenia, and Klaprothieae (Xylopodia, Klaprothia, Plakothira). High bootstrap support values confirm the monophyly both of Klaprothieae and Presliophytum (when expanded to include Loasa ser. Malesherbioideae). Aosa and Blumenbachia are not resolved as monophyletic, but have clear morphological apomorphies. Within Nasa, “N. ser. Saccatae” is paraphyletic, and “N. ser. Carunculatae” is polyphyletic. However, the N. triphylla group in “N. ser. Saccatae” is a well-supported monophyletic group, as is N. ser. Grandiflorae. “Loasa” in its traditional circumscription is paraphyletic, but Loasa s.str. (L. ser. Macrospermae, L. ser. Deserticolae, L. ser. Floribundae) is monophyletic. The remainder of “Loasa” (L. ser. Pinnatae, L. ser. Acaules, L. ser. Volubiles) is probably closely allied to the essentially Patagonian-High Andean group comprising also Scyphanthus and Caiophora. These findings are congruent with morphology and phytogeography. Nasa seems to have undergone its primary radiation at moderate elevations (1500–2500m) in the Andes of northern Peru (Amotape-Huancabamba Zone) and subsequently diversified into high elevations (above 4000m) of the tropical Central Andes. South Andean Loasas appear to have undergone their primary diversification in the southern temperate and mediterranean regions of Chile and Argentina, with a subsequent northwards expansion of Caiophora into the high elevations of the tropical Andes. Hummingbird pollination has evolved independently from melittophily in High Andean clades of Nasa and Caiophora

Specific targeting of human caspases using designed ankyrin repeat proteins

Caspases play important roles in cell death, differentiation, and proliferation. Due to their high homology, especially of the active site, specific targeting of a particular caspase using substrate analogues is very difficult. Although commercially available small molecules based on peptides are lacking high specificity due to overlapping cleavage motives between different caspases, they are often used as specific tools. We have selected designed ankyrin repeat proteins (DARPins) against human caspases 1-9 and identified high-affinity binders for the targeted caspases, except for caspase 4. Besides previously reported caspase-specific DARPins, we generated novel DARPins (D1.73, D5.15, D6.11, D8.1, D8.4, and D9.2) and confirmed specificity for caspases 1, 5, 6, and 8 using a subset of caspase family members. In addition, we solved the crystal structure of caspase 8 in complex with DARPin D8.4. This binder interacts with non-conserved residues on the large subunit, thereby explaining its specificity. Structural analysis of this and other previously published crystal structures of caspase/DARPin complexes depicts two general binding areas either involving active site forming loops or a surface area laterally at the large subunit of the enzyme. Both surface areas involve non-conserved surface residues of caspase

Rheology, dispersion, and cure kinetics of epoxy filled with amine‐ and non‐functionalized reduced graphene oxide for composite manufacturing

This study evaluates the effect of plasma surface functionalization of reduced graphene oxide particles on the processing characteristics and homogeneity of dispersion of a bisphenol A‐(epichlorhydrin) epoxy matrix and amine‐based hardener with varying weight fractions from 0.00 to 1.50 wt%. It was observed that amine‐functionalized reduced graphene oxide leads to a more drastic viscosity increase of up to 18‐fold of the uncured suspensions and that its presence influences the conversion rates of the curing reaction. Optical microscopy of thin sections and transmission electron microscopy analysis showed that a more homogeneous dispersion of the particles could be achieved especially at higher weight fractions by using an appropriate surface functionalization. This knowledge can be used to define suitable processing conditions for epoxies with amine‐based hardeners depending on the loading and functionalization of graphene‐related particles

Mechanical bowel preparation and antimicrobial prophylaxis in elective colorectal surgery in Switzerland—a survey

Background: The aim of this study was to assess the use of mechanical bowel preparation (MBP) and antimicrobial prophylaxis in elective colorectal surgery in Switzerland. Methods: Ninety-eight heads of surgical departments in Switzerland and 42 visceral surgeons in private practice were asked to answer an 18-item questionnaire in October 2008 about arguments in favor of or against MBP. The participants also indicated whether they use MBP and antimicrobial prophylaxis in colorectal surgery, and if so, what agents were used. Of the participants, 117/140 (83%) responded. Additional data were collected pertaining to the respondents' experience and work situation. Results: MBP was used significantly more often for rectal surgery than for left colonic resections (83% vs. 53%; p < 0.001) and more often for left than for right colonic resections (53% vs. 43%; p = 0.001), regardless of the open or laparoscopic approach. Younger surgeons and surgeons with a higher case load in colorectal surgery used MBP significantly less frequently in open right colonic resections. For MBP, cathartics were used in 90% of patients, and enemas were used in 10% of patients. Of the respondents, 37% considered MBP to be useful, even very useful. Based on the literature, because of introduction of fast-track protocols or for considerations of patient comfort, 86% of the respondents had changed the bowel preparation regime during the last 10years in terms of a reduction of the quantity of cathartics or restricted the indications for MBP. Antimicrobial prophylaxis was used by 100% of the respondents, 88% used a single prophylactic dose only, while 70% administered the antibiotics 30-59min before the incision. Most of the surgeons used second-generation cephalosporins in combination with metronidazole, and 24% changed the antibiotic agent or reduced the duration of administration of antibiotics during the last 10years. Conclusions: MBP is often used in open and laparoscopic rectal surgery, but not in right colonic resections. Scientific evidence regarding MBP has yielded a rethinking about rigorous bowel preparation regimes. As of now, surgeons in Switzerland are not yet unanimously ready to abandon MBP in elective colorectal surgery. In Switzerland, surgeons are influenced by the benefit of antimicrobial prophylaxis in colorectal surger